NECTIN4

Chr 1q23.3

nectin cell adhesion molecule 4

Aliases:: nectin-4, PRR4, LNIR
MANE:: ENST00000368012.4

OMIM: 609607 ↗NCBI: 81607 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

NECTIN4 · Q96NY8

v62025-08-01

Predicted Aligned Error matrix for NECTIN4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.8/ 100

Confident

510 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)22%
Low(50–70)10%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Ectodermal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Ectodermal dysplasia without a known gene mutation
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Amelogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal
Palmoplantar keratodermas
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Ectodermal dysplasia - syndactyly syndrome
0.78
urothelial carcinoma
0.51
neoplasm
0.40
urinary bladder carcinoma
0.38
ectodermal dysplasia-syndactyly syndrome
0.38
transitional cell carcinoma
0.37
cancer
0.35
urogenital neoplasm
0.33
urinary bladder cancer
0.30
amelogenesis imperfecta
0.18

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nectin-4

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells