NEFL

Chr 8p21.2

neurofilament light chain

Aliases:: NFL, CMT1F, CMT2E, NF68, PPP1R110
MANE:: ENST00000610854.2

OMIM: 162280 ↗NCBI: 4747 ↗Ensembl ↗

Predicted protein structure

AlphaFold predicted structure

NEFL · P07196

v62025-08-01

Predicted Aligned Error matrix for NEFL — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.1/ 100

Confident

543 residues

Confidence breakdown

Very high(≥ 90)45%
Confident(70–90)14%
Low(50–70)11%
Very low(< 50)30%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Detailed annotations are loading.

We have HGNC metadata for this gene, but the deeper annotations (ClinVar, gnomAD, PanelApp, …) populate when someone uses the GenoLens extension to look up this gene. Install the extension or check back in a moment.