NEK10

Chr 3p24.1

NIMA related kinase 10

Aliases:: FLJ32685
MANE:: ENST00000691995.1

OMIM: 618726 ↗NCBI: 152110 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NEK10 · Q6ZWH5

v62025-08-01

Predicted Aligned Error matrix for NEK10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.6/ 100

Low

1,172 residues

Confidence breakdown

Very high(≥ 90)30%
Confident(70–90)34%
Low(50–70)8%
Very low(< 50)29%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary ciliary disorders
BIALLELIC, autosomal or pseudoautosomal
Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

ciliary dyskinesia, primary, 44
0.73
breast carcinoma
0.50
hypertensive disorder
0.46
breast cancer
0.46
primary ciliary dyskinesia
0.46
breast neoplasm
0.39
luminal A breast carcinoma
0.35
estrogen-receptor positive breast cancer
0.34
nerve plexus disorder
0.31
muscular disease
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serine/threonine-protein kinase Nek10

Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991)