NEK9

Chr 14q24.3

NIMA related kinase 9

Aliases:: Nek8, NERCC, DKFZp434D0935, MGC16714, NERCC1
MANE:: ENST00000238616.10

OMIM: 609798 ↗NCBI: 91754 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NEK9 · Q8TD19

v62025-08-01

Predicted Aligned Error matrix for NEK9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.9/ 100

Confident

979 residues

Confidence breakdown

Very high(≥ 90)44%
Confident(70–90)24%
Low(50–70)8%
Very low(< 50)25%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Mosaic skin disorders - deep sequencing
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

NEK9-related lethal skeletal dysplasia
0.71
arthrogryposis, Perthes disease, and upward gaze palsy
0.64
nevus comedonicus syndrome
0.63
hereditary disease
0.42
neurodegenerative disease
0.38
autoimmune disorder of central nervous system
0.36
Goldberg-Shprintzen syndrome
0.33
Epidermal Inclusion Cyst
0.19
coronary artery disorder
0.17
sebaceous gland disorder
0.14

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serine/threonine-protein kinase Nek9

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158)