neurite extension and migration factor
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Diagnostic Grade (Green)
DDG2P
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)Early onset or syndromic epilepsy
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)Intellectual disability
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)Fetal anomalies
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)X-linked intellectual disability, Cantagrel type
Intellectual disability
hereditary disease
Seizure
epilepsy with myoclonic atonic seizures
X-linked complex neurodevelopmental disorder
neurodevelopmental disorder
developmental and epileptic encephalopathy
Smith-McCort dysplasia 1
Smith-McCort dysplasia
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Neurite extension and migration factor
Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1)
NEXMIF · Q5QGS0
Mean pLDDT
40.6/ 100
Very low
1,516 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
