NEXN

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Dilated and arrhythmogenic cardiomyopathy

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Dilated Cardiomyopathy and conduction defects

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Fetal anomalies

  BIALLELIC, autosomal or pseudoautosomal

• Paediatric or syndromic cardiomyopathy

  BOTH monoallelic and biallelic (but BIALLELIC mutations cause a more SEVERE disease form), autosomal or pseudoautosomal

• Hereditary neuropathy

• Hereditary neuropathy or pain disorder

• Hypertrophic cardiomyopathy

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

• dilated cardiomyopathy 1CC

  0.79

• hypertrophic cardiomyopathy 20

  0.75

• familial isolated dilated cardiomyopathy

  0.67

• hypertrophic cardiomyopathy

  0.58

• cardiomyopathy, dilated, 2M

  0.53

• cardiomyopathy

  0.46

• dilated cardiomyopathy

  0.35

• Abnormality of the cardiovascular system

  0.35

• Left ventricular noncompaction cardiomyopathy

  0.30

• left ventricular noncompaction

  0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with NEXN

Curated MONDO disease pages that list NEXN among their top associated genes.

• familial isolated dilated cardiomyopathyRare