NFKBIA

Chr 14q13.2

NFKB inhibitor alpha

Aliases:: IKBA, MAD-3, IkappaBalpha
MANE:: ENST00000216797.10

OMIM: 164008 ↗NCBI: 4792 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

NFKBIA · P25963

v62025-08-01

Predicted Aligned Error matrix for NFKBIA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.5/ 100

Confident

317 residues

Confidence breakdown

Very high(≥ 90)64%
Confident(70–90)10%
Low(50–70)12%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Ectodermal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Ectodermal dysplasia without a known gene mutation
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Primary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Familial Meniere Disease

Disease associations (Open Targets)

ectodermal dysplasia and immunodeficiency 2
0.75
Hypohidrotic ectodermal dysplasia with immunodeficiency
0.66
psoriasis
0.51
asthma
0.50
Crohn disease
0.49
diffuse large B-cell lymphoma
0.44
inflammatory bowel disease
0.41
psoriasis vulgaris
0.39
hypohidrotic ectodermal dysplasia
0.38
childhood onset asthma
0.38

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

NF-kappa-B inhibitor alpha

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7479976, PubMed:7628694, PubMed:7796813, PubMed:7878466)