AlphaFold predicted structure
NGF · P01138
Mean pLDDT
73.3/ 100
Confident
241 residues
Confidence breakdown
- Very high(≥ 90)37%
- Confident(70–90)22%
- Low(50–70)21%
- Very low(< 50)21%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
NGF
Chr 1p13.2nerve growth factor
- MANE:
- ENST00000369512.3
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Familial dysautonomia
BIALLELIC, autosomal or pseudoautosomalHereditary neuropathy
BIALLELIC, autosomal or pseudoautosomalHereditary neuropathy or pain disorder
BIALLELIC, autosomal or pseudoautosomalPain syndromes
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
Paroxysmal central nervous system disorders
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
hereditary sensory and autonomic neuropathy type 5
0.78osteoarthritis, knee
0.55hypertensive disorder
0.53Pain
0.51osteoarthritis
0.50angina pectoris
0.49spinal stenosis
0.49osteoarthritis, hip
0.49essential hypertension
0.48coronary artery disorder
0.48
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Beta-nerve growth factor
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable) (PubMed:20978020). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity)
Diseases associated with NGF
Curated MONDO disease pages that list NGF among their top associated genes.