NID1

Chr 1q42.3

nidogen 1

Aliases:: entactin
MANE:: ENST00000264187.7

OMIM: 131390 ↗NCBI: 4811 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NID1 · P14543

v62025-08-01

Predicted Aligned Error matrix for NID1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.2/ 100

Confident

1,247 residues

Confidence breakdown

Very high(≥ 90)36%
Confident(70–90)43%
Low(50–70)9%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.42
isolated Dandy-Walker malformation without hydrocephalus
0.37
placental retention
0.28
Peyronie disease
0.26
Hemiparesis
0.26
Hydrocephalus
0.26
focal epilepsy
0.26
autoimmune disorder of central nervous system
0.23
arthritic joint disease
0.22
cerebellar dysfunction with variable cognitive and behavioral abnormalities
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nidogen-1

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions