NLGN4X

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• DDG2P

  X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

• Intellectual disability

  X-LINKED: hemizygous mutation in males, biallelic mutations in females

Disease associations (Open Targets)

• neurodegenerative disease

  0.49

• hereditary disease

  0.47

• autism

  0.47

• X-linked intellectual disability

  0.42

• X-linked complex neurodevelopmental disorder

  0.40

• insomnia

  0.38

• schizophrenia

  0.38

• Intellectual disability

  0.15

• autism spectrum disorder

  0.12

• breast carcinoma

  0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with NLGN4X

Curated MONDO disease pages that list NLGN4X among their top associated genes.

• autismRare