NME5

Chr 5q31.2

NME/NM23 family member 5

Aliases:: nm23-H5, RSPH23
MANE:: ENST00000265191.4

OMIM: 603575 ↗NCBI: 8382 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NME5 · P56597

v62025-08-01

Predicted Aligned Error matrix for NME5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.1/ 100

Very high

212 residues

Confidence breakdown

Very high(≥ 90)80%
Confident(70–90)9%
Low(50–70)5%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

ciliary dyskinesia, primary, 48, without situs inversus
0.58
primary ciliary dyskinesia
0.39
atrial fibrillation
0.25
autoimmune disorder of central nervous system
0.22
spermatogenic failure
0.06
male infertility with azoospermia or oligozoospermia due to single gene mutation
0.06
Young syndrome
0.05
mathematical ability
0.05
congenital factor VII deficiency
0.05
hereditary hemorrhagic telangiectasia
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nucleoside diphosphate kinase 5

Functions as part of axonemal radial spoke complexes, which play an important part in the motility of sperm and cilia (By similarity). In vitro, does not display nucleoside diphosphate kinase (NDPK) activity (Probable) (PubMed:16313181, PubMed:9742940). Exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing (PubMed:16313181). Confers protection from cell death mediated by BAX and alters the cellular levels of several antioxidant enzymes, including GPX5 (By similarity). Might be involved in spermiogenesis by enhancing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity)