AlphaFold predicted structure
NOBOX · O60393
Mean pLDDT
47.5/ 100
Very low
691 residues
Confidence breakdown
- Very high(≥ 90)3%
- Confident(70–90)6%
- Low(50–70)14%
- Very low(< 50)77%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
NOBOX
Chr 7q35NOBOX oogenesis homeobox
- Aliases:
- OG2, Og2x
- MANE:
- ENST00000645489.3
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Primary ovarian insufficiency
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
primary ovarian failure
0.75genetic non-acquired premature ovarian failure
0.49hereditary disease
0.19Hereditary breast cancer
0.11hereditary breast carcinoma
0.11obesity disorder
0.11stroke disorder
0.10alcohol drinking
0.10hepatocellular adenoma
0.05osteoarthritis
0.05
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Homeobox protein NOBOX
Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'