AlphaFold predicted structure
NOS1AP · O75052
Mean pLDDT
64.6/ 100
Low
506 residues
Confidence breakdown
- Very high(≥ 90)37%
- Confident(70–90)7%
- Low(50–70)11%
- Very low(< 50)46%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
NOS1AP
Chr 1q23.3nitric oxide synthase 1 adaptor protein
- Aliases:
- KIAA0464, CAPON
- MANE:
- ENST00000361897.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Proteinuric renal disease
BIALLELIC, autosomal or pseudoautosomalUnexplained young onset end-stage renal disease - additional genes
BIALLELIC, autosomal or pseudoautosomalLong QT syndrome
UnknownShort QT syndrome
Disease associations (Open Targets)
nephrotic syndrome, type 22
0.63neurodegenerative disease
0.49Romano-Ward syndrome
0.39alcohol drinking
0.36smoking cessation
0.32cervical squamous cell carcinoma
0.31immune system disorder
0.31familial long QT syndrome
0.30seasonal allergic rhinitis
0.29knee fracture
0.29
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862)