NOS2

Chr 17q11.2

nitric oxide synthase 2

Aliases:: iNOS, NOS, HEP-NOS
MANE:: ENST00000313735.11

OMIM: 163730 ↗NCBI: 4843 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NOS2 · P35228

v62025-08-01

Predicted Aligned Error matrix for NOS2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.4/ 100

Confident

1,153 residues

Confidence breakdown

Very high(≥ 90)65%
Confident(70–90)22%
Low(50–70)4%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Familial Meniere Disease
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

psoriasis
0.49
psoriasis vulgaris
0.43
psoriatic arthritis
0.38
type 2 diabetes mellitus
0.37
chronic atrophic gastritis
0.31
myocardial infarction
0.28
skin disorder
0.28
acute myocardial infarction
0.26
ankylosing spondylitis
0.20
neoplasm
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nitric oxide synthase, inducible

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109)