NOS3

Chr 7q36.1

nitric oxide synthase 3

Aliases:: ECNOS, eNOS
MANE:: ENST00000297494.8

OMIM: 163729 ↗NCBI: 4846 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NOS3 · P29474

v62025-08-01

Predicted Aligned Error matrix for NOS3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.5/ 100

Confident

1,203 residues

Confidence breakdown

Very high(≥ 90)56%
Confident(70–90)25%
Low(50–70)7%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Cerebral vascular malformations
BIALLELIC, autosomal or pseudoautosomal
Familial Meniere Disease

Disease associations (Open Targets)

hypertensive disorder
0.46
essential hypertension
0.43
myocardial infarction
0.39
coronary artery disorder
0.39
stroke disorder
0.38
heart disorder
0.35
myocardial ischemia
0.34
primary ovarian failure
0.33
cardiovascular disorder
0.32
neurodegenerative disease
0.32

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nanos homolog 3

Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis