NPM1

Chr 5q35.1

nucleophosmin 1

Aliases:: B23, NPM
MANE:: ENST00000296930.10

OMIM: 164040 ↗NCBI: 4869 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

NPM1 · P06748

v62025-08-01

Predicted Aligned Error matrix for NPM1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.3/ 100

Confident

294 residues

Confidence breakdown

Very high(≥ 90)38%
Confident(70–90)16%
Low(50–70)20%
Very low(< 50)27%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Cytopenia - NOT Fanconi anaemia
Unknown
Cytopenias and congenital anaemias
Unknown
Radial dysplasia
Unknown

Disease associations (Open Targets)

cancer
0.68
non-small cell lung carcinoma
0.66
acute myeloid leukemia
0.66
neurodegenerative disease
0.55
HIV infectious disease
0.54
neoplasm
0.53
dyskeratosis congenita
0.51
anaplastic large cell lymphoma
0.41
Hodgkins lymphoma
0.38
lymphoid neoplasm
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nucleophosmin

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity)