AlphaFold predicted structure
NPNT · Q6UXI9
Mean pLDDT
67.2/ 100
Low
565 residues
Confidence breakdown
- Very high(≥ 90)14%
- Confident(70–90)43%
- Low(50–70)12%
- Very low(< 50)31%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
NPNT
Chr 4q24nephronectin
- Aliases:
- EGFL6L, POEM
- MANE:
- ENST00000379987.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
chronic obstructive pulmonary disease
0.56asthma
0.54lower respiratory tract disorder
0.44respiratory system disorder
0.44hypertensive disorder
0.42essential hypertension
0.38major depressive disorder
0.37Chronic Obstructive Asthma
0.36COVID-19
0.36cardiovascular disorder
0.35
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Nephronectin
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity)
Diseases associated with NPNT
Curated MONDO disease pages that list NPNT among their top associated genes.