NPR3

Chr 5p13.3

natriuretic peptide receptor 3

Aliases:: GUCY2B, FLJ14054
MANE:: ENST00000265074.13

OMIM: 108962 ↗NCBI: 4883 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

NPR3 · P17342

v62025-08-01

Predicted Aligned Error matrix for NPR3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.1/ 100

Confident

541 residues

Confidence breakdown

Very high(≥ 90)65%
Confident(70–90)15%
Low(50–70)9%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Familial Meniere Disease
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability

Disease associations (Open Targets)

Boudin-Mortier syndrome
0.69
hypertensive disorder
0.53
essential hypertension
0.48
Increased blood pressure
0.46
Abnormality of the skeletal system
0.45
cardiovascular disorder
0.44
alcohol drinking
0.43
major depressive disorder
0.40
atrial fibrillation
0.39
congestive heart failure
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Atrial natriuretic peptide receptor 3

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity)