NR2F2

Chr 15q26.2

nuclear receptor subfamily 2 group F member 2

Aliases:: COUP-TFII, COUPTFB, SVP40, NF-E3, COUPTF2
MANE:: ENST00000394166.8

OMIM: 107773 ↗NCBI: 7026 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

NR2F2 · P24468

v62025-08-01

Predicted Aligned Error matrix for NR2F2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.8/ 100

Confident

414 residues

Confidence breakdown

Very high(≥ 90)52%
Confident(70–90)15%
Low(50–70)8%
Very low(< 50)25%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Differences in sex development
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Familial non syndromic congenital heart disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

congenital heart defects, multiple types, 4
0.75
46,xx sex reversal 5
0.61
neurodegenerative disease
0.54
familial atrioventricular septal defect
0.51
hereditary disease
0.50
smoking initiation
0.44
congenital heart disease
0.34
intelligence
0.34
testicular disorder
0.33
mathematical ability
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

COUP transcription factor 2

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development (PubMed:29478779)