AlphaFold predicted structure
NR3C1 · P04150
Mean pLDDT
59.6/ 100
Low
777 residues
Confidence breakdown
- Very high(≥ 90)35%
- Confident(70–90)6%
- Low(50–70)4%
- Very low(< 50)56%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
NR3C1
Chr 5q31.3nuclear receptor subfamily 3 group C member 1
- Aliases:
- GR
- MANE:
- ENST00000394464.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Differences in sex development
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedExtreme early-onset hypertension
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
glucocorticoid resistance
0.81chronic obstructive pulmonary disease
0.70multiple sclerosis
0.69rheumatoid arthritis
0.63asthma
0.63plasma cell myeloma
0.62sarcoidosis
0.62infection
0.62autoimmune thrombocytopenic purpura
0.62osteoarthritis
0.62
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Glucocorticoid receptor
Receptor for glucocorticoids (GC) (PubMed:27120390, PubMed:37478846). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors (PubMed:28139699). Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity)
Diseases associated with NR3C1
Curated MONDO disease pages that list NR3C1 among their top associated genes.