AlphaFold predicted structure
NR3C2 · P08235
Mean pLDDT
55.9/ 100
Low
984 residues
Confidence breakdown
- Very high(≥ 90)28%
- Confident(70–90)6%
- Low(50–70)4%
- Very low(< 50)63%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
NR3C2
Chr 4q31.23nuclear receptor subfamily 3 group C member 2
- Aliases:
- MR
- MANE:
- ENST00000358102.8
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Extreme early-onset hypertension
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedRenal tubulopathies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
autosomal dominant pseudohypoaldosteronism type 1
0.78hypertensive disorder
0.74Renal pseudohypoaldosteronism type 1
0.73pseudohyperaldosteronism type 2
0.69heart failure
0.61myocardial infarction
0.60chronic kidney disease
0.60congestive heart failure
0.59type 2 diabetes mellitus
0.59nephrotic syndrome
0.58
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Mineralocorticoid receptor
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels
Diseases associated with NR3C2
Curated MONDO disease pages that list NR3C2 among their top associated genes.