NRAP

Chr 10q25.3

nebulin related anchoring protein

MANE:: ENST00000359988.4

OMIM: 602873 ↗NCBI: 4892 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NRAP · Q86VF7

v62025-08-01

Predicted Aligned Error matrix for NRAP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

52.0/ 100

Low

1,730 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)9%
Low(50–70)47%
Very low(< 50)44%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Paediatric or syndromic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal
Dilated and arrhythmogenic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

dilated cardiomyopathy
0.54
atrial fibrillation
0.44
smoking initiation
0.41
Abnormality of the cardiovascular system
0.38
smoking behavior
0.31
substance abuse
0.28
attention deficit-hyperactivity disorder
0.28
Abnormal erythrocyte morphology
0.28
mitochondrial complex I deficiency
0.27
mitochondrial complex I deficiency, nuclear type 4
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nebulin-related-anchoring protein

May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix