NRDC

Chr 1p32.3

nardilysin convertase

Aliases:: hNRD1, hNRD2
MANE:: ENST00000352171.12

OMIM: 602651 ↗NCBI: 4898 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NRDC · O43847

v62025-08-01

Predicted Aligned Error matrix for NRDC — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.6/ 100

Confident

1,151 residues

Confidence breakdown

Very high(≥ 90)69%
Confident(70–90)14%
Low(50–70)1%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Arthrogryposis
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Optic neuropathy
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

major depressive disorder
0.44
obesity disorder
0.28
attention deficit-hyperactivity disorder
0.28
major depressive episode
0.28
neurodevelopmental disorder
0.27
placental abruption
0.24
microcephaly
0.23
optic nerve disorder
0.23
Optic neuropathy
0.23
complex neurodevelopmental disorder
0.18

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nardilysin

Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity)