NRG3

Chr 10q23.1

neuregulin 3

MANE:: ENST00000372141.7

OMIM: 605533 ↗NCBI: 10718 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

NRG3 · P56975

v62025-08-01

Predicted Aligned Error matrix for NRG3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

50.1/ 100

Low

720 residues

Confidence breakdown

Very high(≥ 90)3%
Confident(70–90)14%
Low(50–70)13%
Very low(< 50)70%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Familial Hirschsprung Disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

cancer
0.58
alcohol drinking
0.37
neurodegenerative disease
0.37
Hirschsprung disease
0.35
respiratory tract infectious disorder
0.35
jaw disease
0.33
gastrointestinal disease
0.31
Aganglionic megacolon
0.31
systemic lupus erythematosus
0.31
smoking initiation
0.30

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Pro-neuregulin-3, membrane-bound isoform

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes