NRROS

Chr 3q29

negative regulator of reactive oxygen species

Aliases:: UNQ3030, ELLP3030, MGC50789, GARPL1
MANE:: ENST00000328557.5

OMIM: 615322 ↗NCBI: 375387 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

NRROS · Q86YC3

v62025-08-01

Predicted Aligned Error matrix for NRROS — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.3/ 100

Confident

692 residues

Confidence breakdown

Very high(≥ 90)54%
Confident(70–90)25%
Low(50–70)15%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Intracerebral calcification disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

seizures, early-onset, with neurodegeneration and brain calcifications
0.74
asthma
0.45
allergic rhinitis
0.39
Eczematoid dermatitis
0.38
respiratory system disorder
0.34
allergic disease
0.32
atopic asthma
0.28
chronic rhinosinusitis
0.27
obesity disorder
0.27
drug allergy
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transforming growth factor beta activator LRRC33

Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 (By similarity). TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS (By similarity). Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (PubMed:23545260)