NT5E

Chr 6q14.3

5'-nucleotidase ecto

Aliases:: CD73, eN, eNT, CALJA
MANE:: ENST00000257770.8

OMIM: 129190 ↗NCBI: 4907 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NT5E · P21589

v62025-08-01

Predicted Aligned Error matrix for NT5E — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.9/ 100

Very high

574 residues

Confidence breakdown

Very high(≥ 90)86%
Confident(70–90)5%
Low(50–70)2%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hereditary arterial and articular multiple calcification syndrome
0.72
non-small cell lung carcinoma
0.33
placental abruption
0.31
Varicose veins
0.25
cardiac hypertrophy
0.24
dermatophytosis
0.24
lower urinary tract calculus
0.24
gram-negative bacterial infections
0.24
Pathologic fracture
0.22
pericarditis
0.22

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

5'-nucleotidase

Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:34403084). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (PubMed:34403084). Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:34403084)