NTN1

Chr 17p13.1

netrin 1

Aliases:: NTN1L, NET1
MANE:: ENST00000173229.7

OMIM: 601614 ↗NCBI: 9423 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NTN1 · O95631

v62025-08-01

Predicted Aligned Error matrix for NTN1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.5/ 100

Confident

604 residues

Confidence breakdown

Very high(≥ 90)70%
Confident(70–90)20%
Low(50–70)4%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Childhood onset dystonia, chorea or related movement disorder
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Monogenic hearing loss
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Limb disorders
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

mirror movements 4
0.66
cleft palate
0.47
cleft lip
0.47
orofacial cleft
0.43
familial congenital mirror movements
0.39
lacrimal apparatus disorder
0.34
placental abruption
0.29
multinodular goiter
0.28
sweat gland disorder
0.28
response to antihypertensive drug
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Netrin-1

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335)