NTNG2

Chr 9q34.13

netrin G2

Aliases:: KIAA1857, Lmnt2, NetrinG2
MANE:: ENST00000393229.4

OMIM: 618689 ↗NCBI: 84628 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NTNG2 · Q96CW9

v62025-08-01

Predicted Aligned Error matrix for NTNG2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.5/ 100

Confident

530 residues

Confidence breakdown

Very high(≥ 90)56%
Confident(70–90)28%
Low(50–70)9%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia
0.75
neurodevelopmental disorder
0.39
complex neurodevelopmental disorder
0.37
Global developmental delay
0.34
Areflexia
0.33
Generalized hypotonia
0.33
Stereotypical hand wringing
0.33
urolithiasis
0.29
alcohol drinking
0.29
Achalasia
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Netrin-G2

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites