NUDT2

Chr 9p13.3

nudix hydrolase 2

MANE:: ENST00000379158.7

OMIM: 602852 ↗NCBI: 318 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

NUDT2 · P50583

v62025-08-01

Predicted Aligned Error matrix for NUDT2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

94.9/ 100

Very high

147 residues

Confidence breakdown

Very high(≥ 90)88%
Confident(70–90)8%
Low(50–70)3%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy or pain disorder
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

intellectual developmental disorder with or without peripheral neuropathy
0.66
Intellectual disability
0.46
polyneuropathy
0.37
Global developmental delay
0.37
Hypotonia
0.37
complex neurodevelopmental disorder
0.27
melanoma
0.07
neoplasm
0.05
placenta praevia
0.04
placental retention
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Catalyzes the asymmetric hydrolysis of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield AMP and ATP (By similarity). Exhibits decapping activity towards FAD-capped RNAs and dpCoA-capped RNAs in vitro (By similarity)