NUDT6

Chr 4q28.1

nudix hydrolase 6

Aliases:: gfg-1, gfg, FGF2AS, FGF-AS
MANE:: ENST00000304430.10

OMIM: 606261 ↗NCBI: 11162 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NUDT6 · P53370

v62025-08-01

Predicted Aligned Error matrix for NUDT6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.7/ 100

Confident

316 residues

Confidence breakdown

Very high(≥ 90)77%
Confident(70–90)8%
Low(50–70)1%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Osteogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Abnormality of the skeletal system
0.44
atrial fibrillation
0.40
neurodegenerative disease
0.40
type 2 diabetes mellitus
0.16
arthropathy
0.13
concussion
0.11
diabetes mellitus
0.11
myasthenia gravis
0.10
triple-A syndrome
0.04
ovarian dysfunction
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nudix hydrolase 6

Mediates the hydrolysis of some nucleoside diphosphate derivatives, such as NADH and FAD (in vitro) (PubMed:37343711). May contribute to the regulation of cell proliferation (PubMed:11266510)