AlphaFold predicted structure
NUP85 · Q9BW27
Mean pLDDT
84.2/ 100
Confident
656 residues
Confidence breakdown
- Very high(≥ 90)54%
- Confident(70–90)31%
- Low(50–70)5%
- Very low(< 50)9%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
NUP85
Chr 17q25.1nucleoporin 85
- Aliases:
- NUP75, FLJ12549
- MANE:
- ENST00000245544.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Proteinuric renal disease
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
nephrotic syndrome
0.64HIV infectious disease
0.54influenza
0.54viral infectious disease
0.53Seckel syndrome
0.37microcephalic primordial dwarfism
0.37COVID-19
0.37Histiocytosis
0.37familial idiopathic steroid-resistant nephrotic syndrome
0.37systemic sclerosis
0.17
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Nuclear pore complex protein Nup85
Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872). The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356). NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708). Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708). Involved in nephrogenesis (PubMed:30179222)
Diseases associated with NUP85
Curated MONDO disease pages that list NUP85 among their top associated genes.