NUP93

Chr 16q13

nucleoporin 93

Aliases:: KIAA0095
MANE:: ENST00000308159.10

OMIM: 614351 ↗NCBI: 9688 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

NUP93 · Q8N1F7

v62025-08-01

Predicted Aligned Error matrix for NUP93 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.9/ 100

Confident

819 residues

Confidence breakdown

Very high(≥ 90)21%
Confident(70–90)60%
Low(50–70)13%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Proteinuric renal disease
BIALLELIC, autosomal or pseudoautosomal
Unexplained kidney failure in young people
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

nephrotic syndrome, type 12
0.69
familial idiopathic steroid-resistant nephrotic syndrome
0.60
influenza
0.54
HIV infectious disease
0.54
viral infectious disease
0.53
Alzheimer disease
0.46
Parkinson disease
0.46
lysosomal storage disease
0.46
neurodegenerative disease
0.46
multiple sclerosis
0.46

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nuclear pore complex protein Nup93

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725)

Curated MONDO disease pages that list NUP93 among their top associated genes.

viral infectious diseaseRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with NUP93