AlphaFold predicted structure
NUP98 · P52948
Mean pLDDT
55.7/ 100
Low
1,817 residues
Confidence breakdown
- Very high(≥ 90)5%
- Confident(70–90)34%
- Low(50–70)10%
- Very low(< 50)52%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
NUP98
Chr 11p15.4nucleoporin 98 and 96 precursor
- Aliases:
- NUP96, Nup98-Nup96, Nup98-96, NUP196
- MANE:
- ENST00000324932.12
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Familial Hirschsprung Disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
influenza
0.54HIV infectious disease
0.54viral infectious disease
0.53acute myeloid leukemia
0.40lung carcinoma
0.38lymphoid neoplasm
0.37COVID-19
0.37endometrial endometrioid adenocarcinoma
0.37hepatobiliary neoplasm
0.37cutaneous melanoma
0.37
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Nuclear pore complex protein Nup98-Nup96
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC (PubMed:33097660). May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134). Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body) (PubMed:28221134)
Diseases associated with NUP98
Curated MONDO disease pages that list NUP98 among their top associated genes.