NXN

Chr 17p13.3

nucleoredoxin

Aliases:: FLJ12614, NRX
MANE:: ENST00000336868.8

OMIM: 612895 ↗NCBI: 64359 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

NXN · Q6DKJ4

v62025-08-01

Predicted Aligned Error matrix for NXN — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.6/ 100

Confident

435 residues

Confidence breakdown

Very high(≥ 90)67%
Confident(70–90)26%
Low(50–70)2%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Limb disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

robinow syndrome, autosomal recessive 2
0.61
Robinow syndrome
0.60
autosomal recessive Robinow syndrome
0.38
colorectal cancer
0.37
polyp of colon
0.33
benign colon neoplasm
0.30
vertebral column disorder
0.28
inflammatory bowel disease
0.28
spinal cord injury
0.28
benign neoplasm of pituitary gland
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Nucleoredoxin

Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity)