NYNRIN

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

• Childhood solid tumours

  BIALLELIC, autosomal or pseudoautosomal

• Familial hypercholesterolaemia

Disease associations (Open Targets)

• neurodegenerative disease

  0.39

• type 2 diabetes mellitus

  0.37

• Hypercholesterolemia

  0.26

• hypogonadism

  0.20

• physical activity

  0.20

• alcohol drinking

  0.20

• Wilms tumor

  0.19

• response to statin

  0.18

• Wilms tumor 1

  0.16

• hepatoblastoma

  0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.