AlphaFold predicted structure
ODC1 · P11926
Mean pLDDT
88.0/ 100
Confident
461 residues
Confidence breakdown
- Very high(≥ 90)77%
- Confident(70–90)10%
- Low(50–70)2%
- Very low(< 50)11%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
ODC1
Chr 2p25.1ornithine decarboxylase 1
- Aliases:
- ODC
- MANE:
- ENST00000234111.9
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownCOVID-19 research
UnknownPrimary immunodeficiency or monogenic inflammatory bowel disease
Unknown
Disease associations (Open Targets)
neurodevelopmental disorder with alopecia and brain abnormalities
0.72human African trypanosomiasis
0.49neoplasm
0.40trypanosomiasis
0.39neurodevelopmental disorder
0.37leishmaniasis
0.37Hirsutism
0.37autoimmune disorder of central nervous system
0.35Familial adenomatous polyposis
0.33neurodegenerative disease
0.31
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Ornithine decarboxylase
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis
Diseases associated with ODC1
Curated MONDO disease pages that list ODC1 among their top associated genes.