OLFM2

Chr 19p13.2

olfactomedin 2

Aliases:: OlfC, NOE2
MANE:: ENST00000264833.9

OMIM: 617492 ↗NCBI: 93145 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

OLFM2 · O95897

v62025-08-01

Predicted Aligned Error matrix for OLFM2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.7/ 100

Confident

454 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)26%
Low(50–70)12%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Abnormality of the skeletal system
0.28
vertebral column disorder
0.20
liver disorder
0.14
esophageal disorder
0.14
musculoskeletal system disorder
0.14
metabolic dysfunction-associated steatotic liver disease
0.09
immune system disorder
0.08
obesity disorder
0.08
obesity due to melanocortin 4 receptor deficiency
0.08
Obesity
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Noelin-2

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity)