ONECUT1

Chr 15q21.3

one cut homeobox 1

Aliases:: HNF-6
MANE:: ENST00000305901.7

OMIM: 604164 ↗NCBI: 3175 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ONECUT1 · Q9UBC0

v62025-08-01

Predicted Aligned Error matrix for ONECUT1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

59.4/ 100

Low

465 residues

Confidence breakdown

Very high(≥ 90)26%
Confident(70–90)3%
Low(50–70)14%
Very low(< 50)58%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Neonatal diabetes
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.53
type 2 diabetes mellitus
0.48
neonatal diabetes mellitus
0.46
hypertensive disorder
0.41
diabetes mellitus
0.41
Abnormality of the skeletal system
0.37
obesity disorder
0.35
benign neoplasm of eye
0.32
Abdominal obesity
0.31
essential hypertension
0.31

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Hepatocyte nuclear factor 6

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription