OPN1LW

Chr Xq28

opsin 1, long wave sensitive

Aliases:: COD5
MANE:: ENST00000369951.9

OMIM: 300822 ↗NCBI: 5956 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

OPN1LW · P04000

v62025-08-01

Predicted Aligned Error matrix for OPN1LW — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.2/ 100

Confident

364 residues

Confidence breakdown

Very high(≥ 90)56%
Confident(70–90)27%
Low(50–70)3%
Very low(< 50)15%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Retinal disorders
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Disease associations (Open Targets)

blue cone monochromacy
0.62
red color blindness
0.61
Blue cone monochromatism
0.61
red-green color blindness
0.47
Progressive cone dystrophy
0.39
Cone rod dystrophy
0.39
cone-rod dystrophy
0.39
Rod-cone dystrophy
0.39
retinitis pigmentosa
0.10
open-angle glaucoma
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Long-wave-sensitive opsin 1

G protein-coupled photoreceptor that selectively activates G(i) proteins in response to long-wavelength (red) light, thereby decreasing intracellular cAMP levels (PubMed:2937147, PubMed:6140680, Ref.5). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (Ref.5). Mediates visual perception of red light in cone photoreceptor cells (PubMed:12051694, PubMed:8213841, PubMed:8666378)