AlphaFold predicted structure
ORC6 · Q9Y5N6
Mean pLDDT
81.8/ 100
Confident
252 residues
Confidence breakdown
- Very high(≥ 90)56%
- Confident(70–90)26%
- Low(50–70)4%
- Very low(< 50)14%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
ORC6
Chr 16q11.2origin recognition complex subunit 6
- MANE:
- ENST00000219097.7
Annotations refreshed 11 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalDeafness and congenital structural abnormalities
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalIUGR and IGF abnormalities
BIALLELIC, autosomal or pseudoautosomalSevere microcephaly
BIALLELIC, autosomal or pseudoautosomalSkeletal dysplasia
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalMonogenic short stature
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Ear-patella-short stature syndrome
0.78neurodegenerative disease
0.52Meier-Gorlin syndrome
0.38microcephalic primordial dwarfism
0.37hereditary disease
0.19neoplasm
0.10cancer
0.10central nervous system cancer
0.09glioma
0.09non-small cell lung carcinoma
0.09
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Origin recognition complex subunit 6
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3