OTOA

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Monogenic hearing loss

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• hearing loss, autosomal recessive

  0.70

• Rare genetic deafness

  0.53

• deafness

  0.45

• Non-syndromic genetic deafness

  0.39

• hearing loss disorder

  0.37

• nonsyndromic genetic hearing loss

  0.37

• autosomal recessive nonsyndromic hearing loss 7

  0.30

• autosomal recessive nonsyndromic hearing loss 1A

  0.28

• major depressive disorder

  0.24

• dysthymic disorder

  0.20

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)