OTOG

Chr 11p15.1

otogelin

Aliases:: mlemp, OTGN, FLJ46346
MANE:: ENST00000399397.6

OMIM: 604487 ↗NCBI: 340990 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

OTOG · Q6ZRI0-2isoform

No predicted structure exists for the canonical Q6ZRI0 sequence; metrics below describe this isoform.

v62025-08-01

Predicted Aligned Error matrix for OTOG — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

59.9/ 100

Low

1,508 residues

Confidence breakdown

Very high(≥ 90)10%
Confident(70–90)40%
Low(50–70)8%
Very low(< 50)43%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hearing loss, autosomal recessive
0.71
Rare genetic deafness
0.53
deafness
0.46
Hearing impairment
0.44
nonsyndromic genetic hearing loss
0.44
Non-syndromic genetic deafness
0.39
Meniere disease
0.38
Vertigo
0.34
central nervous system origin vertigo
0.33
peripheral vertigo
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Otogelin

Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity)