OTOGL

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• DDG2P

  BIALLELIC, autosomal or pseudoautosomal

• Monogenic hearing loss

  BIALLELIC, autosomal or pseudoautosomal

• Fetal anomalies

  BIALLELIC, autosomal or pseudoautosomal

• Intellectual disability

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• hearing loss, autosomal recessive

  0.73

• Rare genetic deafness

  0.53

• vestibular disorder

  0.46

• nonsyndromic genetic hearing loss

  0.44

• central nervous system origin vertigo

  0.44

• peripheral vertigo

  0.44

• Vertigo

  0.43

• Non-syndromic genetic deafness

  0.38

• hereditary disease

  0.34

• inner ear disorder

  0.31

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Diseases associated with OTOGL

Curated MONDO disease pages that list OTOGL among their top associated genes.

• hearing loss, autosomal recessiveRare