P2RY12

Chr 3q25.1

purinergic receptor P2Y12

Aliases:: P2Y12, SP1999, HORK3
MANE:: ENST00000302632.4

OMIM: 600515 ↗NCBI: 64805 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

P2RY12 · Q9H244

v62025-08-01

Predicted Aligned Error matrix for P2RY12 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.4/ 100

Confident

342 residues

Confidence breakdown

Very high(≥ 90)59%
Confident(70–90)22%
Low(50–70)8%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Bleeding and platelet disorders
BIALLELIC, autosomal or pseudoautosomal
Inherited bleeding disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

platelet-type bleeding disorder 8
0.71
P2Y12 defect
0.67
myocardial infarction
0.62
acute coronary syndrome
0.61
Stroke
0.61
coronary artery disorder
0.60
peripheral vascular disease
0.60
stroke disorder
0.59
peripheral arterial disease
0.56
angina unstable
0.56

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

P2Y purinoceptor 12

Receptor for ADP and ATP coupled to G proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation

Curated MONDO disease pages that list P2RY12 among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with P2RY12