PAN2

Chr 12q13.3

poly(A) specific ribonuclease subunit PAN2

Aliases:: KIAA0710, hPAN2
MANE:: ENST00000440411.8

OMIM: 617447 ↗NCBI: 9924 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PAN2 · Q504Q3

v62025-08-01

Predicted Aligned Error matrix for PAN2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.0/ 100

Confident

1,202 residues

Confidence breakdown

Very high(≥ 90)36%
Confident(70–90)43%
Low(50–70)9%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.50
syndromic complex neurodevelopmental disorder
0.18
psoriasis
0.17
psoriasis vulgaris
0.10
colorectal carcinoma
0.08
type 2 diabetes mellitus
0.08
coronary artery disorder
0.08
bladder transitional cell carcinoma
0.07
non-small cell lung carcinoma
0.07
skin disorder
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Retinol dehydrogenase 14

Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroid