PARN

Chr 16p13.12

poly(A)-specific ribonuclease

Aliases:: DAN
MANE:: ENST00000437198.7

OMIM: 604212 ↗NCBI: 5073 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

PARN · O95453

v62025-08-01

Predicted Aligned Error matrix for PARN — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

81.1/ 100

Confident

639 residues

Confidence breakdown

Very high(≥ 90)62%
Confident(70–90)16%
Low(50–70)3%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Childhood interstitial lung disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Familial pulmonary fibrosis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Haematological malignancies cancer susceptibility
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Haematological malignancies for rare disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

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Disease associations (Open Targets)

idiopathic pulmonary fibrosis
0.79
dyskeratosis congenita
0.78
pulmonary fibrosis
0.59
telomere syndrome
0.42
Hoyeraal-Hreidarsson syndrome
0.37
type 1 diabetes nephropathy
0.34
paralytic strabismus
0.34
interstitial lung disease
0.26
metabolic syndrome
0.23
Uterine leiomyoma
0.22

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Poly(A)-specific ribonuclease PARN

3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (PubMed:10882133, PubMed:11359775, PubMed:12748283, PubMed:15175153, PubMed:9736620). Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (PubMed:22442037, PubMed:25049417)