PDCD10

Chr 3q26.1

programmed cell death 10

Aliases:: TFAR15
MANE:: ENST00000392750.7

OMIM: 609118 ↗NCBI: 11235 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

PDCD10 · Q9BUL8

v62025-08-01

Predicted Aligned Error matrix for PDCD10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.8/ 100

Very high

212 residues

Confidence breakdown

Very high(≥ 90)83%
Confident(70–90)10%
Low(50–70)3%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cerebral vascular malformations
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

famililal cerebral cavernous malformations
0.75
cerebral cavernous malformation
0.56
neurodegenerative disease
0.49
hereditary disease
0.41
cerebral cavernous malformation 1
0.34
cavernous hemangioma
0.28
Seizure
0.27
Hemiparesis
0.27
Cerebral arteriovenous malformation
0.27
drug allergy
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Programmed cell death protein 10

Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity)