PDCD2

Chr 6q27

programmed cell death 2

Aliases:: ZMYND7, RP8
MANE:: ENST00000541970.6

OMIM: 600866 ↗NCBI: 5134 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

PDCD2 · Q16342

v62025-08-01

Predicted Aligned Error matrix for PDCD2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.8/ 100

Confident

344 residues

Confidence breakdown

Very high(≥ 90)63%
Confident(70–90)18%
Low(50–70)12%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.52
hydrops fetalis
0.37
hepatocellular carcinoma
0.18
Congenital ptosis
0.09
retinitis pigmentosa
0.09
Marcus-Gunn syndrome
0.08
congenital fibrosis of the extraocular muscles
0.08
Duane retraction syndrome
0.08
cancer
0.07
ptosis, hereditary congenital, 1
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

uS5 assembly chaperone PDCD2

Chaperone for ribosomal protein uS5; cotranslationally associates with uS5 and accompanies the ribosomal protein to assembly sites in the nucleus; appears to function redundantly to PDCD2L