PDE11A

Chr 2q31.2

phosphodiesterase 11A

MANE:: ENST00000286063.11

OMIM: 604961 ↗NCBI: 50940 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

PDE11A · Q9HCR9

v62025-08-01

Predicted Aligned Error matrix for PDE11A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.2/ 100

Confident

933 residues

Confidence breakdown

Very high(≥ 90)46%
Confident(70–90)30%
Low(50–70)4%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary pigmented nodular adrenocortical disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

primary pigmented nodular adrenocortical disease
0.63
myopia
0.47
refractive error
0.42
smoking initiation
0.39
Carney complex
0.39
Progressive visual loss
0.38
sleep apnea syndrome
0.36
substance-related disorder
0.31
radiculitis
0.29
Abnormality of refraction
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148)

Curated MONDO disease pages that list PDE11A among their top associated genes.

myopiaRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with PDE11A