PDE8B

Chr 5q13.3

phosphodiesterase 8B

MANE:: ENST00000264917.10

OMIM: 603390 ↗NCBI: 8622 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PDE8B · O95263

v62025-08-01

Predicted Aligned Error matrix for PDE8B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.1/ 100

Confident

885 residues

Confidence breakdown

Very high(≥ 90)48%
Confident(70–90)20%
Low(50–70)5%
Very low(< 50)27%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary pigmented nodular adrenocortical disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Parkinson Disease and Complex Parkinsonism
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

autosomal dominant striatal neurodegeneration type 1
0.59
coronary artery disorder
0.54
stroke disorder
0.53
pigmented nodular adrenocortical disease, primary, 3
0.52
hypothyroidism
0.51
dysuria
0.46
thyroid gland disorder
0.46
hyperthyroidism
0.46
thyrotoxicosis
0.45
nodular goiter
0.44

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland